Synthesis Analgesic, Anti-inflammatory and Antimicrobial Activities of Some 1-[5-(substituted Phenyl)-4,5-dihydro-1h- Pyrazol-3-yl]-5-phenyl-1h-tetrazole

Eight different derivatives of substituted 5-phenyl-1-(5-substituted phenyl) -4,5-dihydro1H-pyrazol-3-yl)-1H-tetrazole (4a-h) were synthesized by reacting the chalcones with hydrazine hydrate in presence of glacial acetic. The chemical structures were confirmed by means of FT-IR, H-NMR, mass spectra and elemental analysis. The compounds were screened for analgesic activity by acetic acid induced writhing method and hot plate method, antiinflamatory and antimicrobial activities. The observed increase in analgesic, anti-inflammatory and antimicrobial activities are attributed to the presence of 4-NO2, 4OH and 4-Cl in phenyl ring at 5-position of pyrazoline ring of synthesized compounds. In some cases their activities are equal or more potent than the standard drugs.